diff --git a/dlls/ntdll/unix/sync.c b/dlls/ntdll/unix/sync.c
index e303367c29f..3723d21f885 100644
--- a/dlls/ntdll/unix/sync.c
+++ b/dlls/ntdll/unix/sync.c
@@ -2788,10 +2788,39 @@ NTSTATUS WINAPI NtDelayExecution( BOOLEAN alertable, const LARGE_INTEGER *timeou
     }
     else
     {
+        LONGLONG ticks = timeout->QuadPart;
         LARGE_INTEGER now;
-        timeout_t when, diff;
+        timeout_t when = ticks, diff;
 
-        if ((when = timeout->QuadPart) < 0)
+#if defined(HAVE_CLOCK_GETTIME) && defined(HAVE_CLOCK_NANOSLEEP)
+        static BOOL disable_clock_nanosleep = FALSE;
+        if (!disable_clock_nanosleep && ticks != 0)
+        {
+            struct timespec when;
+            int err;
+
+            if (ticks < 0)
+            {
+                clock_gettime( CLOCK_REALTIME, &when );
+                when.tv_sec += (time_t)(-ticks / TICKSPERSEC);
+                when.tv_nsec += (long)((-ticks % TICKSPERSEC) * 100);
+            }
+            else
+            {
+                when.tv_sec = (time_t)((ticks / TICKSPERSEC) - SECS_1601_TO_1970);
+                when.tv_nsec = (long)((ticks % TICKSPERSEC) * 100);
+            }
+
+            usleep(0);
+            while ((err = clock_nanosleep( CLOCK_REALTIME, TIMER_ABSTIME, &when, NULL )) == EINTR);
+            if (!err)
+                return STATUS_SUCCESS;
+            else
+                disable_clock_nanosleep = TRUE;
+        }
+#endif
+
+        if (when < 0)
         {
             NtQuerySystemTime( &now );
             when = now.QuadPart - when;